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Current Challenges and Proposed Solutions to the Effective Implementation of the RTS, S/AS01 Malaria Vaccine Program in Sub-Saharan Africa: A Systematic Review

Current Challenges and Proposed Solutions to the Effective Implementation of the RTS, S/AS01 Malaria Vaccine Program in Sub-Saharan Africa: A Systematic Review

Author: 
Christian Akem Dimala
Belmond Tse Kika
Benjamin Momo Kadia
Hannah Blencowe
Publication Date
Monday, December 31, 2018
Affiliation: 

University Hospitals of Leicester (Dimala); Health and Human Development (2HD) Research Network (Dimala); Universite Libre de Bruxelles (Kika); Clinical Research Education, Networking and Consultancy Group, or CRENC (Kika); London School of Hygiene and Tropical Medicine, or LSHTM (Kadia, Blencowe); Grace Community Health and Development Association (Kadia)

The Malaria Vaccine Implementation Program, coordinated by the World Health Organization (WHO), intended to initiate the roll-out of the RTS, S/AS01 malaria vaccine in 3 sub-Saharan African countries (Ghana, Kenya, Malawi) in 2018. This study had as objectives to systematically review and summarise studies published between 1947 and 2017 that address the challenges faced during the implementation phase of malaria vaccination programmes and randomised trials conducted in sub-Saharan Africa (SSA). The review also sought to report proposed solutions to the challenges identified.

The 8 studies included in the review had a total of 6,189 participants and used a variety of methodologies (3 qualitative, 1 quantitative, 3 mixed method studies, and 1 clinical trial review). Of the participants, 1,157 were involved in the qualitative studies. These included parents, caregivers, health professionals, community leaders, teachers, religious leaders, and other key stakeholders.

  <div class="field button"><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209744" target="_blank">Click here to read the article online or to download it in PDF format (11 pages)</a></div>
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Source: 

PLoS ONE 13(12): e0209744. https://doi.org/10.1371/journal.pone.0209744. Image credit: Gavi, the Vaccine Alliance

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